Possible Interaction: Glutathione and Hesperidin

“Also, the pre- or posttreatment by HSP and/or TAU significantly minimized CCl 4 -induced reduction of superoxide dismutase, catalase, reduced glutathione , and albumin concentrations.”

“ HES induced significant increase in tissue and serum glutathione with significant decrease in tumor volume and tumor weight.”

“ Hesperidin significantly (p < 0.001) reduced the levels of thiobarbituric acid reactive substance and increased the level of superoxide dismutase, glutathione , glutathione peroxidase, catalase in OVX‐induced rats.”

“ HDN decreased malondialdehyde content, but increased the levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione.”

“Moreover, hesperidin attenuated the depleted content of reduced glutathione ( GSH ) and elevated level of thiobarbituric acid reactive substances (TBARS) and also augmented lipid alteration significantly following ICV-STZ injection.”

“A significantly depleted activity of antioxidant enzymes, glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT) and superoxide dismutase (SOD) and content of glutathione (GSH) in MCAO group were protected significantly in MCAO group pretreated with hesperidin.”

“ Colonic glutathione levels in colitic animals were significantly increased after hesperidin or diosmin treatment.”

“In the aqueous humour, hesperidin treatment increased the glutathione level 125%, 184.4% and 231.2% at 25, 50 and 100 mg/kg of hesperidin respectively.”

“Results demonstrated that HD inhibited DMH mediated oxidative damage by diminishing the level of peroxidation of lipids and increasing the activity of superoxide dismutase, catalase, reduced glutathione , glutathione peroxidase, glutathione‐s‐transferase, and glutathione reductase.”

“However, GSH and MDA levels were modulated after hesperidin consumption.”