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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Heparin
Research Papers that Mention the Interaction
“Both AO staining of DNA and mBBr staining of protamines revealed that the addition of heparin to GSH but not to DTT significantly increased the thiol reduced status of sperm chromatin.”
Heparin enhances protamine disulfide bond reduction during in vitro decondensation of human spermatozoa.“UFH also decreased the cellular GSH content in the HL60/doxo cells with respect to the control, suggesting a potential involvement of UFH in doxo co-transport with GSH.”
“However, GSH at concentrations as low as 0.1 mM in combination with heparin induces decondensation of human sperm nuclei in vitro.”
“After 60 min of in vitro decondensation with glutathione plus heparin , the percentage of decondensed sperm heads was significantly higher in treated males than in controls (mean ± s.d.:”
Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake.“Only the combination of heparin plus a reducing agent such as glutathione triggered the release of siRNA from the conjugate.”
“Nevertheless, nucleons reach 95% of chromatin decondensation in the presence of heparin plus GSH or heparin alone.”
“The fact that the correlation between heparin and GSH concentrations needed to induce sperm nuclei decondensation was 3- to 4-fold greater that in nucleons might be due to the complete lack of nucleon membranes.”
“Therefore, rupture of disulfide bridges is not the main mechanism to induce nuclei decondensation and perhaps the GSH role resides in potentate the heparin effect by increasing its negative charge.”
“ Glutathione reverses the inhibition of PCMB but relieves heparin inhibition only 50%.”
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