Possible Interaction: Glutathione and Green Tea Extract

“The tea extracts significantly reduced GSH and increased GSSG levels in G6PD-deficient erythrocytes in a dose-dependent manner (0.5-10 mg/ml), but not in normal erythrocytes.”

“ GTE caused significant glutathione depletion and this effect likely contributed to the observed potentiation.”

“ GTP supplementation resulted in increased urinary epigallocatechin and epicatechin concentrations, liver glutathione peroxidase activity and femur bone mineral density, decreased urinary 8-hydroxy-2′-deoxyguanosine and urinary calcium levels, but no effect on serum estradiol and blood chemistry levels.”

“Bioactive ingredients of green tea extract caused in the liver an increase in the activity of glutathione peroxidase and glutathione reductase and in the content of reduced glutathione as well as marked decrease in lipid hydroperoxides (LOOH), 4-hydroksynonenal (4-HNE) and malondialdehyde (MDA).”

“ GTE at 40 and 80 µg/ml significantly promoted cell survival and upregulated antioxidant enzyme activities (CAT, SOD, GPx) and endogenous antioxidant GSH , while the gene and protein expression levels were significantly restored through its effective antioxidant mechanism.”

“Malondialdehyde (MDA) levels, glutathione GSH ), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus were increased by long-term treatment with GTex and EGCG.”

“The cytotoxicity of a 4-hr exposure of the GTP extract to the HSC-2 and GT1, but not to the HGF-2, cells was lessened in the presence of 2.5 mM GSH.”