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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Grape Seed Extract
Research Papers that Mention the Interaction
“ GSE treatment decreased the mitochondrial electron transport chain complex III activity, increased the mitochondrial superoxide levels and depleted the levels of cellular antioxidant ( glutathione ), thus resulting in the loss of mitochondrial membrane potential in human HNSCC Detroit 562 and FaDu cells.”
Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells“Consistent with this, GSE also decreased intracellular level of reduced glutathione.”
“ GSE could also reduce the exhaustion of GSH levels in mice liver.”
[Anti-lipoperoxidation of grape seed extracts in vitro].“… GSE resulted in a … plasma glutathione ( GSH ) level (+265.5 ± 344.2 vs. +2.2 ± 378.2 µmol/L, P = 0.02), as well as a significant decrease …) level (-1.4 ± 2.0 vs. -0.2 ± 1.2 µmol/L, P = 0.01) when compared to the placebo group.”
Grape Seed Extract Supplementation and the Effects on the Biomarkers of Oxidative Stress and Metabolic Profiles in Female Volleyball Players: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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