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Last Updated: 2 years ago

Possible Interaction: Glutathione and Glycine

supplement:

Glutathione

supplement:

Glycine

Research Papers that Mention the Interaction

Oral GSH supplementation is not the most efficient option due to the enzymatic degradation of ingested GSH within the intestine by γ-glutamyltransferase, but supplementation of its component amino acids—cysteine, glycine , and glutamate—enhances tissue GSH synthesis.
Nutrients  •  2019  |  View Paper
It is provided from diets and endogenous synthesis, and its conversion into glycine enhances the production of glutathione , DNA, heme, and protein.
Antioxidants & redox signaling  •  2019  |  View Paper
Removal of the Gly residue from the glutathione molecule caused a 13-fold increase in the KM value for the electrophilic substrate.
Biochemistry  •  1996  |  View Paper
GLY enhanced GSH levels under GLN starvation, but caused a diminution of GSH content under optimal GLN supply.
Clinical nutrition  •  2003  |  View Paper
Replacement of part of the plasma of whole blood with isotomic phosphate buffer does not significantly elevate glycine passage into the blood cells, the incorporation of glycine into GSH is, however, markedly accelerated.
Biochimica et biophysica acta  •  1965  |  View Paper
In addition to the above abnormalities, there is a decreased glycine incorporation rate into GSH in vitro, an increase in glutathione reductase,
American journal of diseases of children  •  1964  |  View Paper
The oncorporation in vitro of glycine into glutathione of whole blood in 12 h is 4–12 times higher than that of l -glutamic acid.
Biochimica et biophysica acta  •  1964  |  View Paper
The rate of incorporation of glycine into glutathione in deficient cells was found to be lower than in normal cells.
Biochimica et biophysica acta  •  1959  |  View Paper
The biochemical … that GLY treatment remarkably altered the transcriptional levels of HSP70 and HSP90; inhibited the … SOD, CAT, GPx, GR, and T-AOC; reduced the contents of GSH , but remarkably promoted MDA and PC contents, suggesting that GLY exposure … stress and lipids and proteins damage in the carp gills.
Environmental pollution  •  2019  |  View Paper
Furthermore, GLY decreased the concentrations of total glutathione and reduced glutathione (GSH), as well as GSH/oxidized glutathione ratio in vivo in hippocampus.
In vitro data also showed that GLY induced lipid peroxidation and decreased GSH in striatum.
Molecular Neurobiology  •  2018  |  View Paper
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