Possible Interaction: Glutathione and Glutamate

“ GSH microinjection increased mean arterial pressure (MAP) compared to vehicle and abrogated responses to subsequent injection of l-glutamate.”

“These data indicate that GSH microinjection into the NTS affects blood pressure regulation by dorsomedial neuronal circuits and blunts l-glutamate driven excitation in this region.”

“Increases (P < 0.05) in GSH concentrations were observed using l-cysteine, 1.0 mM l-glutamate , l-alpha-aminobutyrate, and l-alpha-aminobutyrate with BME.”

“ gamma-L-glutamylglycine and beta-L-aspartylglycine moderately inhibited the Na(+)-dependent uptake of L-glutamate and D-aspartate while the other peptides were only weak inhibitors.”

“It was recently … addition of L-glutamate in millimolar amounts to a culture of C6 glioma cells induced cell death within 24 h. The … glutamate toxicity in the C6 glioma cells is linked to the inhibition of cystine uptake, leading to glutathione depletion through the cystine/… antiporter (Xc) system.”