Possible Interaction: Glutathione and Gentamicin

“Treatment with GNT increased the serum levels of renal function parameters and renal MDA, NF-κB and KIM-1 mRNA levels, while it decreased GSH and SOD activities.”

“Initially, gentamicin treatment significantly (p<0.05)reduced thelevels of antioxidant enzymes (SOD, CAT, GPx) and GSH and increased (p<0.05) the levels of creatinine, uric acid, urea, inflammatory markers (nitrite, IL-6, TNF- α, iNOS) and lipid peroxidation.”

“In addition, GM also significantly decreased (p < 0.001) the renal superoxide dismutase (SOD), reduced glutathione ( GSH ), B-cell lymphoma 2 (Bcl-2) mRNA expression, and mitochondrial enzymes (NADH dehydrogenase and cytochrome c oxidase) activities.”

“ Gentamicin caused a significant decrease or inhibition in the activities of GSH , SOD, and CAT, with significant increase in the level of MDA, ALT, AST, ALP, as well as creatinine, uric acid and urea concentrations in versus to control groups in both liver and kidney.”

“On the other hand, GM reduced the GSH level and SOD, CAT activities.”

“The results revealed that gentamicin significantly increases MDA and HNE contents, but decreases GSH and NO levels; and ascorbic acid on co-administration has capability to inhibit drug-induced lipid peroxidation.”

“ Gentamicin decreased the activities of catalase (CAT), gutathione peroxidase (GSHPx) and the level of glutathione (GSH) but the activity of copper, zinc-superoxide dismutase (Cu, Zn-SOD) was unaltered compared to control.”

“creatinine and lipid peroxidation (LPO) … was found after administration of gentamicin (80 mg/kg/day, ip) for eight days along with … decrease in the antioxidant enzymes, superoxide dismutase (SOD), reduced glutathione ( GSH ), catalase (CAT) as well as brush border enzymes (Na+/K+ ATPase, Mg(+2)ATPase and Ca2+ ATPase).”

“Treatment of rats with gentamicin resulted in statistically significant reduction in reduced glutathione levels (51%) and the activities of antioxidant enzymes superoxide dismutase (56%) and glutathione peroxidase (39%) as compared with the controls in the kidneys.”

“AG administration with GEN injection resulted in significantly decreased MDA, NO generation and increased GSH-Px, SOD, CAT activities and GSH content when compared with GEN alone.”