Possible Interaction: Glutathione and Genistein

“It is established thatl day after irradiation the level of reduced glutathione in the rats treated with genistein was 26% higher.”

“Additionally, the endogenous antioxidants SOD, CAT and GSH appear to play a role in the antioxidant activity of genistein.”

“ Genistein increased superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels and attenuated the decrease in these antioxidants during oxidative stress.”

“Exposure to genistein significantly increased hGSTP1 mRNA (2.3-fold), hGSTP1-1 protein levels (3.1-fold), GST catalytic activity (4.7-fold) and intracellular glutathione concentrations (1.4-fold) in MCF-10A cells, whereas no effects were observed on GST expression or glutathione concentrations in MCF-7 cells.”

“ GNT pretreatment increased hepatic glutathione levels in PQ + GNT group.”

“In addition, GE treatment significantly elevated the activities of total antioxidant capacity and superoxide dismutase and the level of glutathione and lowered the content of malondialdehyde in the cortex and hippocampus of CSD‐treated mice.”

“ Genistein significantly decreased the production of intracellular MDA and GSH and increased SOD and GSH PX activity.”

“ Genistein decreased malondialdehyde levels and increased glutathione levels in liver homogenates, regardless of dose.”

“Puerarin and genistein were shown to have μM sTOSCs at least ten-fold greater than sTOSC of glutathione.”

“Whereas glutathione selectively enhances light induction of genistein conjugates, methyl jasmonate enhances both light and PWG-induced isoflavone conjugate accumulations.”