Possible Interaction: Glutathione and Ferric Ion

“Meanwhile, ferric ions Fe(iii) ) can oxidize the intracellular GSH to GSSG, thus depleting the concentration of GSH inside tumors.”

“Ascorbic acid and reduced glutathione were able to enhance this lipid peroxidation, presumably by facilitating the reduction of ferric ion.”

“The increase in immunoreactivity noted with Fe2+/Fe3+ or Mn2+ can be blocked with either EDTA or antioxidants ( GSH and ascorbic acid), suggesting that it takes place during a peroxidative reaction of the lipids.”

“Ascorbate, glutathione , and 1,4-benzoquinone all reduce ferric TyrH, but much more slowly than tetrahydrobiopterin, suggesting that the pterin is a physiological reductant.”

“Similarly, glutathione (1.0, 2.0, 4.0, 5.0, or 6.0 mM) inflicted damage on calf thymus DNA in the presence of Fe3+ (3.0 μM).”

“The released Fe(III) ions could trigger GSH depletion and Fenton reaction, activating chemodynamic therapy (CDT).”

“Fe(II) then reduces H2O2, and in turn Fe(III) and the oxidized cluster are re-reduced by cellular reductants such as NADPH and glutathione.”

“The relative concentrations of these two … are a function of pH. Glutathione , a biologically relevant reducing agent, binds to the ferric iron --bleomycin complex, reduces it, and may serve as a model for the reduction of the ferric iron--bleomycin complex to the ferrous state during the catalytic cycle.”