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Last Updated: 2 years ago

Possible Interaction: Glutathione and Epoprostenol

supplement:

Glutathione

Research Papers that Mention the Interaction

GSH modulated PGI2 synthesis In all carotid specimens except areas of ulceratlon (p<0.05), but did not restore PGI2 formation In atheromatous fractions to basal level.
Arteriosclerosis  •  1988  |  View Paper
In this study, PGI2 synthetase activity of bovine coronary arterial microsomes could be altered over a 2-3 fold range by GSH or dithiothreitol in a concentration-dependent manner and over a microsomal protein range of 10-200 micrograms.
Biochemical and biophysical research communications  •  1984  |  View Paper
Sulfhydryl containing compounds such as captopril, N-acetylcysteine and glutathione decreased PGI2 production via increased [cGMP]i.
Japanese circulation journal  •  1991  |  View Paper
Both H2O2-induced cell injury and PGI2 production were significantly inhibited by the 3 h pretreatment with GSH.
Prostaglandins, leukotrienes, and essential fatty acids  •  1992  |  View Paper
The cytoprotective effect and the stimulatory effect on PGI2 production, where both were dose-dependent on GSH , were in a strict reverse relationship.
Toxicology  •  1991  |  View Paper
These data suggest the possibility that changes in GSH concentration may modulate eicosanoid formation in cells that contain GSH-dependent PGE2 isomerase, as well as either or both prostacyclin or thromboxane synthase(s).
Biochimica et biophysica acta  •  1990  |  View Paper