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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Epoprostenol
Research Papers that Mention the Interaction
“ GSH modulated PGI2 synthesis In all carotid specimens except areas of ulceratlon (p<0.05), but did not restore PGI2 formation In atheromatous fractions to basal level.”
Prostacyclin, Thromboxane A2, and Prostaglandin E2 Formation in Atherosclerotic Human Carotid Artery“In this study, PGI2 synthetase activity of bovine coronary arterial microsomes could be altered over a 2-3 fold range by GSH or dithiothreitol in a concentration-dependent manner and over a microsomal protein range of 10-200 micrograms.”
“Sulfhydryl containing compounds such as captopril, N-acetylcysteine and glutathione decreased PGI2 production via increased [cGMP]i.”
“Both H2O2-induced cell injury and PGI2 production were significantly inhibited by the 3 h pretreatment with GSH.”
Cytoprotective effect of reduced glutathione in hydrogen peroxide-induced endothelial cell injury.“The cytoprotective effect and the stimulatory effect on PGI2 production, where both were dose-dependent on GSH , were in a strict reverse relationship.”
“These data suggest the possibility that changes in GSH concentration may modulate eicosanoid formation in cells that contain GSH-dependent PGE2 isomerase, as well as either or both prostacyclin or thromboxane synthase(s).”
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