Possible Interaction: Glutathione and Epigallocatechin Gallate

“Importantly, the polyphenol coating EGCg ) used in this study could be biodegraded by acidic pH and intracellular glutathione , resulting in the release of trapped anticancer drugs.”

“In the cells incubated with EGCG , the consumption of alpha-Toc and the formation of the oxidized form of GSH were suppressed.”

“Malathion significantly reduced GSH content, but pre-treatment with EGCG significantly recovered GSH content.”

“The cotreatment with SF and EGCG was effective in reducing ROS production, increasing GSH levels, and enhancing the endogenous antioxidant defences through the upregulation of glutathione reductase, NAD(P)H:quinone oxidoreductase-1, and thioredoxin reductase.”

“Compared with MC-LR, EGCG significantly increased superoxide dismutase (SOD) and glutathione (GSH) levels and decreased malondialdehyde (MDA) levels.”

“ EGCG reduced the glutathione levels, which might be responsible for enhanced ROS generation causing oxidative stress in endometrial cancer cells.”

“However, EGCG pretreatment significantly increased the activities of GSH , antioxidant enzymes and membrane bound ATPases.”

“In G6PD-deficient cells, GSH was reduced by 43.3% (EGC at 0.05 mg/ml) and 33.3% ( EGCG at 0.5 mg/ml), compared with pre-challenged levels.”

“ EGCG (10 μM) treatment reduced the ROS and MDA levels, while increased the antioxidant capacity and GSH concentrations in the mature oocytes.”

“… EGCG significantly decreased H2O2-reduced cell viability and apoptotic cells with DNA damage, … antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), glutathione (GSH), and glutathione disulfide (GSSG), and suppressed the increase in intracellular reactive … oxide synthesis (NOS), malondialdehyde (MDA), lipid peroxide (LPO), and protein carbonyl (Carbonyl).”