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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Ebselen
Research Papers that Mention the Interaction
“…,ebselen lowered concentrations of inositol (p = …) as well as those of glutathione (p = 0.033, d = 0.58), glutamine (p = 0.024, d = 0.62), glutamate (p = 0.01, d = 0.…, d = 1.0).ConclusionsThe study suggests that ebselen produces a functional inhibition of IMPase in the human brain.”
Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla“ Ebselen lost its high protection against 3-triol-induced injuries in the presence of GSH probably due to the formation of the ebselen-GSH adduct.”
“Both ebselen and PDTC increased cellular levels of reduced glutathione.”
“Treatment of HepG2 cells with ebselen increased glutathione levels after 12 (1.5-fold) or 24 (1.9-fold)h of treatment.”
“Stimulation of GSH peroxidation with ebselen potentiated the H(2)O(2)-induced oscillating Ca(2+) response and the bleb formation, but not p38 phosphorylation.”
“It was found that (i) ebselen rapidly depleted intracellular GSH and protein thiols, moreover, the depletion preceded the occurrence of apoptosis; (ii) NAC, a precursor of intracellular GSH synthesis, significantly alleviated ebselen-induced apoptosis; and (iii) BSO, a specific inhibitor of intracellular GSH synthesis, augmented ebselen-induced apoptosis significantly.”
“Meanwhile, we revealed that ebselen can increase glutathione (GSH) content as well as superoxide dismutase (SOD) and catalase (CAT) activities after SCI-this suggests ebselen has an antioxidant effect.”
Ebselen protects mitochondrial function and oxidative stress while inhibiting the mitochondrial apoptosis pathway after acute spinal cord injury“Investigation of the drug's antifungal mechanism of action indicates that ebselen depletes intracellular glutathione ( GSH ) levels, leading to increased production of reactive oxygen species (ROS), and thereby disturbs the redox homeostasis in fungal cells.”
“The silver and ebselen combination causes a rapid depletion of glutathione and inhibition of the thioredoxin system in bacteria.”
“N-Acetyl-L-cysteine (NAC) also reduced the increase in glutathione to some extent, whereas both peroxynitrite scavenger ebselen and hydroxyl radical scavenger DMSO inhibited the increase in glutathione in a dose-dependent manner and complete inhibition was observed.”
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