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Last Updated: a year ago

Possible Interaction: Glutathione and Ebselen





Research Papers that Mention the Interaction

…,ebselen lowered concentrations of inositol (p = …) as well as those of glutathione (p = 0.033, d = 0.58), glutamine (p = 0.024, d = 0.62), glutamate (p = 0.01, d = 0.…, d = 1.0).ConclusionsThe study suggests that ebselen produces a functional inhibition of IMPase in the human brain.
Psychopharmacology  •  2015  |  View Paper
Ebselen lost its high protection against 3-triol-induced injuries in the presence of GSH probably due to the formation of the ebselen-GSH adduct.
Biochimica et biophysica acta  •  2006  |  View Paper
Both ebselen and PDTC increased cellular levels of reduced glutathione.
Chemistry & biology  •  2006  |  View Paper
Treatment of HepG2 cells with ebselen increased glutathione levels after 12 (1.5-fold) or 24 (1.9-fold)h of treatment.
Archives of biochemistry and biophysics  •  2004  |  View Paper
Stimulation of GSH peroxidation with ebselen potentiated the H(2)O(2)-induced oscillating Ca(2+) response and the bleb formation, but not p38 phosphorylation.
Biochimica et biophysica acta  •  2002  |  View Paper
It was found that (i) ebselen rapidly depleted intracellular GSH and protein thiols, moreover, the depletion preceded the occurrence of apoptosis; (ii) NAC, a precursor of intracellular GSH synthesis, significantly alleviated ebselen-induced apoptosis; and (iii) BSO, a specific inhibitor of intracellular GSH synthesis, augmented ebselen-induced apoptosis significantly.
Archives of biochemistry and biophysics  •  2000  |  View Paper
Meanwhile, we revealed that ebselen can increase glutathione (GSH) content as well as superoxide dismutase (SOD) and catalase (CAT) activities after SCI-this suggests ebselen has an antioxidant effect.
Neuroscience Letters  •  2018  |  View Paper
Investigation of the drug's antifungal mechanism of action indicates that ebselen depletes intracellular glutathione ( GSH ) levels, leading to increased production of reactive oxygen species (ROS), and thereby disturbs the redox homeostasis in fungal cells.
Biochimica et biophysica acta. General subjects  •  2017  |  View Paper
The silver and ebselen combination causes a rapid depletion of glutathione and inhibition of the thioredoxin system in bacteria.
EMBO molecular medicine  •  2017  |  View Paper
N-Acetyl-L-cysteine (NAC) also reduced the increase in glutathione to some extent, whereas both peroxynitrite scavenger ebselen and hydroxyl radical scavenger DMSO inhibited the increase in glutathione in a dose-dependent manner and complete inhibition was observed.
Biological & pharmaceutical bulletin  •  2005  |  View Paper
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