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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“After that, the thiol-ene click reaction was initiated to couple GSH and DHA to deplete intracellular GSH.”
A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition.“We recently showed that DHA upregulates glutathione ( GSH ) content via an induction of its related enzymes γ-glutamylcysteine ligase and glutathione reductase.”
“Investigating the mechanism underlying DHA‐induced apoptosis, we showed that DHA induced a rapid and dramatic (>60%) intracellular depletion of reduced glutathione ( GSH ), without affecting oxidized glutathione (GSSG).”
“ DHA induced low glutathione levels in RBCs, indicating that oxidative stress may be involved in artemisinin toxicity; effects were extremely rapid, with altered RBCs seen as early as GD10.”
In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos.“We suggest that DHA plays an important role in inducing an antioxidative defense against active oxygen by enhancing the cerebral activities of CAT, GPx, and GSH.”
“In addition, GSH modulated the cellular redox balance through maintaining increased GSH: GSSG and AsA: DHA ratios, and also increased phytochelatins contents.”
Glutathione-mediated regulation of nitric oxide, S-nitrosothiol and redox homeostasis confers cadmium tolerance by inducing transcription factors and stress response genes in tomato.
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