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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glutathione
drug:
Docetaxel
Research Papers that Mention the Interaction
“In addition, our data showed that the mechanism of radiopotentiation by docetaxel probably does not involve a G2/M block in SMMC-7721 cells, and ROS generation and GSH deletion may play a key role in the radiosensitizing effect of docetaxel.”
“The ROS of SMMC-7721 cells increased and GSH decreased after pretreatment with the same doses of docetaxel for 24 or 48 h. CONCLUSION A radiosensitizing effect of docetaxel could be demonstrated unambiguously in this cell line used.”
Docetaxel shows radiosensitization in human hepatocellular carcinoma cells.“Results In the SH-SY5Y cells, DTX induced a significant reduction of total glutathione (P < 0.001) and ascorbic acid (P < 0.05), and an increase in both total F2-Isoprostanes (P < 0.05) and catalase activity (P < 0.05), as compared to untreated cells.”
Redox imbalance induced by docetaxel in the neuroblastoma SH-SY5Y cells: a study of docetaxel-induced neuronal damage“The release studies revealed significantly accelerated docetaxel (DTX) release in the presence of 10 mM glutathione.”
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