Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Glutathione and Dimesna

supplement:

Glutathione

drug:

Dimesna

Research Papers that Mention the Interaction

“Moreover, DIMESNA may deprive the cell of glutathione and thus enhance the toxicity of 4-OOH-CP.”
Dithio-bis-mercaptoethanesulphonate (DIMESNA) does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in LLC-PK1 cells
Pediatric Nephrology  •  2004  |  View Paper
“Small increases in liver slice reduced glutathione levels and glutathione S-transferase activity were also observed after DIM treatment.”
Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  1999  |  View Paper
“ Dimesna reduction was decreased by agents that deplete glutathione.”
Reduction of dimesna to mesna by the isolated perfused rat liver.
Cancer research  •  1998  |  View Paper
“After glomerular filtration, dimesna is reduced by interaction with the glutathione system of the renal tubular cells and is excreted in the urine as mesna, the free thiol compound.”
Prevention of urotoxic side effects by regional detoxification with increased selectivity of oxazaphosphorine cytostatics.
IARC scientific publications  •  1986  |  View Paper