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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Glutathione
supplement:
Diallyl Trisulfide
Research Papers that Mention the Interaction
“In particular, the addition of GSH to DATS in GM released the fastest and highest amounts of H2S among the four H2S donors in the following order: DATS > DADS > Na2S ~ NaHS.”
Characterization of H2S releasing properties of various H2S donors utilizing microplate cover-based colorimetric assay.“The reactivity of DATS with GSH was higher than DPTS.”
Diallyl trisulfide inhibits platelet aggregation through the modification of sulfhydryl groups.“In addition, DATS pretreatment markedly suppressed the ethanol-induced decrease of the hepatic GSH level and increased the mitochondrial GSH level.”
“In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably.”
“… allitridum … GSH levels and decreased MDA formation in CCL-149, the most significant time being incubation at 24 h. The GSH content were (13.34 +/- 0.… prot when CCL-149 cells were treatment with 0, 0.1, 1.0, 5.0 microg/ml of allitridum for 24 h, respectively.”
“GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48-84%) in red blood cells (P < 0.05).”
“In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively).”
“The trisulfide bond also shows higher glutathione sensitivity compared to the conventional disulfide bond, and this sensitivity enables efficient tumor-specific drug release.”
Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity“As a …, DADS and DATS significantly suppressed the increases in biomarkers for hepatic injury such as the activities of aspartate transaminase (…), alanine transaminase (ALT) and lactate dehydrogenase (LDH), and decreases in antioxidative potency such as glutathione ( GSH ) level and the activities of glutathione …-transferase (GST) and glutathione peroxidase (GPx).”
“Our computed potential energy surfaces revealed that GSH and Cys are capable of releasing H2S from DATS and that DADS is a much poorer H2S donor than DATS.”
“Diallyl trisulfide DATS ) reacts rapidly with glutathione (GSH) to release H2S through thiol-disulfide exchange followed by allyl perthiol reduction by GSH.”
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