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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glutathione
Research Papers that Mention the Interaction
“ P450 inhibitors reduced turnover of the drug, production of the glutathione adduct, irreversible binding, and cytotoxicity but inhibited glutathione depletion selectively.”
Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore“Pretreatment of hepatocytes with P450 inhibitors , e.g., phenylimidazole, prevented tBHP-enhanced 4-HA metabolism, GSH depletion, and cytotoxicity.”
Cytochrome P450 peroxidase/peroxygenase mediated xenobiotic metabolic activation and cytotoxicity in isolated hepatocytes.
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