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Possible Interaction: Glutathione and Cupric Cation




Cupric Cation

Research Papers that Mention the Interaction

Meanwhile, the redox reaction between the released Cu2+ ions and intracellular GSH will induce GSH depletion and reduce Cu2+ to Fenton agent Cu+ ions, and then trigger the H2 O2 to generate • OH by a Cu+ -mediated Fenton-like reaction, resulting in enhanced CDT efficacy.
Advanced materials  •  2021  |  View Paper
In contrast, glutathione rapidly dimerizes in the presence of Cu2+ , the reaction competing with S-nitrosation and therefore preventing the formation of S-nitrosoglutathione.
The Journal of Biological Chemistry  •  1999  |  View Paper
D,L-Homocysteine (HCY, 1 mM) and glutathione (GSH, 1 mM) similarly inhibited Cu2+ -dependent, while facilitating Fe3+-dependent, oxidation of LDL.
Thus, Cu2+ -dependent oxidation of LDL was most effectively inhibited by GSH , an intermediate effect was observed with HCY, and CYS was least effective.
Biochimica et biophysica acta  •  1997  |  View Paper
Moreover, the released Cu2+ can act as a smart reactive oxygen species (ROS) protector by consuming intracellular GSH.
ACS applied materials & interfaces  •  2019  |  View Paper
In this work, by making use of a complex formed by Cu2+ and glutathione , which may exhibit excellent voltammetric response, we have proposed a novel potential electrochemical method for the detection of the enzyme.
International journal of molecular sciences  •  2012  |  View Paper
Our results indicate that cupric ions are reduced by GSH and thus are converted from an inhibitor to an enhancer of iron-induced lipid peroxidation.
Lipids  •  2006  |  View Paper
In the presence of GSH, Cu++ derived from SOD may promote the formation of toxic thionyl radicals, metal-centered radicals, and/or H2O2, thereby causing cell injury.
Free radical biology & medicine  •  1995  |  View Paper
The same compounds, GSH , dithiothreitol, N-acetylcysteine, mercaptopropionylglycine and DL-penicillamine protected the enzyme from inactivation by Cu(II) (Tables 2, 4-6).
Medicina  •  1994  |  View Paper
The enhanced cytotoxicity of HQ by Cu(II) could be completely prevented by adding BCS, glutathione (GSH), or dithiothreitol but not by catalase.
Archives of biochemistry and biophysics  •  1993  |  View Paper
The action of both Cu2+ and Zn2+ was reversed by glutathione.
Journal of steroid biochemistry  •  1988  |  View Paper
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