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“Meanwhile, the redox reaction between the released Cu2+ ions and intracellular GSH will induce GSH depletion and reduce Cu2+ to Fenton agent Cu+ ions, and then trigger the H2 O2 to generate • OH by a Cu+ -mediated Fenton-like reaction, resulting in enhanced CDT efficacy.”
“In contrast, glutathione rapidly dimerizes in the presence of Cu2+ , the reaction competing with S-nitrosation and therefore preventing the formation of S-nitrosoglutathione.”
The Journal of Biological Chemistry • 1999 | View Paper
“D,L-Homocysteine (HCY, 1 mM) and glutathione (GSH, 1 mM) similarly inhibited Cu2+ -dependent, while facilitating Fe3+-dependent, oxidation of LDL.”
“Thus, Cu2+ -dependent oxidation of LDL was most effectively inhibited by GSH , an intermediate effect was observed with HCY, and CYS was least effective.”
ACS applied materials & interfaces • 2019 | View Paper
“In this work, by making use of a complex formed by Cu2+ and glutathione , which may exhibit excellent voltammetric response, we have proposed a novel potential electrochemical method for the detection of the enzyme.”
“In the presence of GSH, Cu++ derived from SOD may promote the formation of toxic thionyl radicals, metal-centered radicals, and/or H2O2, thereby causing cell injury.”
Free radical biology & medicine • 1995 | View Paper
“The same compounds, GSH , dithiothreitol, N-acetylcysteine, mercaptopropionylglycine and DL-penicillamine protected the enzyme from inactivation by Cu(II) (Tables 2, 4-6).”