Possible Interaction: Glutathione and Crocin

“ Crocin decreases pulmonary MDA and increases SOD, GSH and catalase.”

“ Crocin not only restored CSE-depleted GSH levels by enhancing GCL expression via activation of Nrf2 but also quenched the CSE-generation and release of reactive oxygen species.”

“In addition, crocin caused significant reductions of malondialdehyde levels and total oxidant score while antioxidant levels ( glutathione , superoxide dismutase, total antioxidant score, and catalase) were significantly higher in PD+Cr group (p < 0.05).”

“Further results indicated that crocin significantly inhibited oxidative stress in serum and liver tissue of THS rats, with increased levels of superoxide dismutase, catalase, and glutathione , and also reduced levels of malondialdehyde and myeloperoxidase levels.”

“It was observed that Cr administration significantly increased GSH , SOD, CAT, TAS, and HDL levels when compared with the control group.”

“However, the CRO administration caused an increase in glutathione , superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase and total sulphydryl levels and a decrease in malondialdehyde content, gamma glutamyl transferase and lipid hydroperoxides levels and proinflammatory cytokines.”

“ Crocin treatment could significantly increase superoxide dismutase (P < 0.05) and glutathione (P < 0.01) levels and reduce malondialdehyde and TNF-α in comparison with the METH group (P < 0.05).”

“Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture.”

“In addition, crocin reduced muscular lipid peroxidation (LPO) and Nrf2 expression and increased glutathione production and glutathione peroxidase activity.”

“ Crocin (10, 20, and 40 mg/kg) or levodopa plus malathion decreased MDA and increased GSH.”