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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Conjugated Linoleic Acid
Research Papers that Mention the Interaction
“ CLA was more potent than arachidonic acid in inducing GSH synthesis.”
Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation“The CLA treatment induced an intracellular GSH increase, matched by high concentration of NADPH, and an increase of γ-glutamyl-cysteine ligase activity mainly in cells treated with the t10,c12 CLA isomer.”
Conjugated linoleic acid isomers strongly improve the redox status of bovine mammary epithelial cells (BME-UV1).“In the liver, CLA reduced the oxidized form of glutathione and elevated the activity of glutathione-dependent antioxidant enzymes.”
“The t10c12 CLA treatment significantly reduced reactive oxygen species level and increased glutathione concentrations in MII oocyte.”
“In vivo, CLA administration drastically reduced SLE signs (splenomegaly, autoantibodies, and cytokine synthesis), a condition paralleled by the enhancement of GCLC expression and intracellular GSH content.”
“… CLA exerted apparently opposed activities in in vitro experiments, depending on its concentration: 100 microM … proliferation of splenocytes, in association with apoptosis induction and a decrease of intracellular thiols ( GSH + GSSG), whereas 25 microM CLA did not significantly influence cell …-glutamylcysteine ligase catalytic subunit (GCLC) and intracellular GSH concentration.”
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