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Last Updated: 2 years ago

Possible Interaction: Glutathione and Carboplatin

supplement:

Glutathione

Research Papers that Mention the Interaction

The higher doses of carboplatin (192 and 256 mg/kg) significantly increased cochlear lipid peroxidation (132 and 146% of control) and depleted cochlear glutathione levels (66 and 63% of control), respectively.
Hearing Research  •  2001  |  View Paper
Glutathione decreased the available CBDCA concentration, decreased apoptosis and alleviating oxidative stress, thus reducing the actual effective concentration.
Molecular medicine reports  •  2018  |  View Paper
GSH enhances the reactivity of three anti-cancer drugs (cisplatin, carboplatin and oxaliplatin) to Cox17, but suppresses the reaction of transplatin.
The Biochemical journal  •  2015  |  View Paper
The low reactivity of carboplatin with metallothionein and glutathione suggests that its low cytotoxic activities are not due to reaction of Pt2+ with cellular thiols.
Cancer Chemotherapy and Pharmacology  •  2005  |  View Paper
Elevated levels of GSH render some types of cancer cells resistant against well-known platinum anti-cancer drugs such as cisplatin and carboplatin.
Journal of inorganic biochemistry  •  2002  |  View Paper
In addition, the BSO and carboplatin chinchillas also had larger decreases in evoked response amplitudes suggesting that GSH depletion potentiated the ototoxicity of carboplatin.
Noise & health  •  1999  |  View Paper