Possible Interaction: Glutathione and Caffeic Acid

“It is notable that adding 100 μM Caffeic acid to freezing extenders enhances the CAT, GPx, SOD, and GSH and also ameliorates total antioxidant capacity of spermatozoa after thawing.”

“In vitro, caffeic acid increases levels of glutathione , glutathione peroxidase, and catalase; it also inhibits LPS-stimulated inflammation by decreasing activation of NF-κB and levels of IL-6, IL-8, TNF-α, and IL-1β.”

“Resveratrol and caffeic acid prevented malondialdehyde accumulation and preserved glutathione , glutathione peroxidase, and catalase activities in erythrocytes.”

“This effect seems to be due to the ability of caffeic acid to reduce glutathione depletion and to inhibit lipid peroxidation during tBOOH treatment.”

“There was an increased glucose uptake, glutathione level, superoxide dismutase, and catalase activities in brain tissues incubated with CA compared to the controls.”

“However, with increased glutathione content, CAFF also halted the activated Notch signaling cascade.”

“Our results show that CA significantly inhibit the TPA induced lipid peroxidation (LPO), inflammatory responses, tumor necrosis factor alpha (TNF-α) release and also found to up regulate GSH content and the activity of different antioxidant enzymes.”

“Pretreatment with CA (15 mg/kg) to ISO-treated rats significantly (P < 0.05) prevented the changes in the activities of cardiac marker enzymes, the levels of lipid peroxidation products, reduced glutathione and the activities of lysosomal enzymes in the serum, heart, and subcellular fractions.”

“These compounds inhibited bacterial growth through a bactericidal effect, which revealed cell killing but no lysis of PL cells after 18 h. Incubation with CAIE , CABE, and CAPE at their MICs significantly increased reactive oxygen species levels and significantly changed glutathione levels within PL cells.”

“The reported beneficial antioxidant, anti-inflammatory and anticancer effects of caffeic acid and p-coumaric acid may be related to their prooxidant-antioxidant balance in the presence of GSH.”