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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Bucillamine
Research Papers that Mention the Interaction
“ Bucillamine , a cysteine derivative that contains two donatable thiol groups, is capable of replenishing the thiol group in glutathione , thereby reactivating this endogenous defense against oxidant injury.”
Bucillamine: a potent thiol donor with multiple clinical applications.“ Bucillamine induces the intranuclear translocation of Nrf2 and thereby increases the expression of γ-glutamylcysteine synthetase (γ-GCS) and glutathione synthetase (GSS), which further induces intracellular antioxidant glutathione ( GSH ), heme oxygenase 1 (HO-1) and superoxide dismutase 2 (SOD2).”
Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes“The GSH concentration and the GSH/GSSG ratio in the retinas decreased in diabetic rats not treated with bucillamine; bucillamine inhibited the decrease of the GSH concentrations.”
“Administration of high doses of BA (150-400 mg/kg) produced a dose-dependent depletion (20-44%) of hepatic GSH , which was similar in magnitude to that produced by equimolar doses of other sulphydryl drugs studied previously.”
“It is possible that BA may affect the redox status through auto-oxidation and oxidation with endogenous thiols such as glutathione , affecting GSH concentrations and the GSH/GSSG ratio in tissues and, thus, having both metabolic and toxicological consequences.”
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