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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glutathione
drug:
Bortezomib
Research Papers that Mention the Interaction
“These data suggest the role of Nrf2, HO-1 and GSH as molecular targets to improve the efficacy of low doses of bortezomib in the treatment of malignant neuroblastoma.”
Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib“ Bortezomib treatment decreases intracellular glutathione both in MM cell lines and in malignant plasma cells obtained from MM patients.”
“ Bortezomib elevated the amount of glutathione (GSH) and the treatment with bortezomib increased the level of mRNA for GCL, a rate-limiting enzyme in glutathione synthesis.”
“Furthermore, depletion of GSH increases apoptosis induced by bortezomib , in contrast, repletion of GSH decreases bortezomib-mediated cell death.”
“Meanwhile, Bortezomib pretreatment also remarkably augmented oxidative stress related protein levels of Superoxide dismutase [Cu-Zn] (SOD1), Catalase (CAT) and Glutathione (GSH), while reactive oxygen species (ROS) contents and Malonaldehyde (MDA) protein level were significantly reduced.”
Bortezomib alleviates myocardial ischemia reperfusion injury via enhancing of Nrf2/HO-1 signaling pathway.
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