Possible Interaction: Glutathione and Bismuth Subsalicylate

“ GSH is essential for both drug detoxification and protein thiol homeostasis within the ER, thus inhibiting ER stress induction and promoting survival, an effect independent of its antioxidant role.”

“Conversely, increasing GSH levels attenuated TCBQ-induced protein damage, degree of ER stress , and cell death.”

“Therefore, GSH has the ability to inhibit ER stress and promote cell survival.”

“Recent research has highlighted a regulatory role for glutathione in influencing the expression of many genes important in plants' responses to both abiotic and biotic stress.”

“The results suggest that glutathione may be playing an important role in protein metabolism in a variety of disease and stress states.”

“Glutathione GSH ) has long been implicated in the defence reaction against biotic stress.”

“At the same time, acid stress increased the uptake of GSH , while ethanol stress led to cell depolarization.”

“Under NaHCO3 stress, activities of superoxide dismutase, peroxidase, catalase, ascorbate peroxidase, dehydroascorbatereductase, monodehydrodroascorbate reductase, and glutathione reductase as well as contents of ascorbic acid and glutathione were firstly increased and then decreased with progress of stress time.”

“ Glutathione content was increased by ER stress , which was accompanied by induction of glutathione biosynthesis genes (GSH1, GSH2).”

“Furthermore, Ni stress also showed a desynchronized antioxidant system by increasing the activities of catalase, peroxidase, and the contents of ascorbic acid and glutathione , whereas decreasing the activity of superoxide dismutase in the roots and shoots of rice plants.”

“ GSH content and most of the antioxidative and glyoxalase enzymes were up-regulated upon Cu stress , indicating their responses were co-related with the level of stress.”