Possible Interaction: Glutathione and Atorvastatin

“ Atorvastatin significantly improved the levels of MDA, SOD, GPx, GSH , but not ALT, AST, and ALP in Cadmium chloride-treated rats.”

“ Atorvastatin and alcohol decreased the reduced form of glutathione in hepatic tissues and induced insulin resistance.”

“ Atorvastatin prevented MPTP-induced increase in reactive species (RS) generation and in glutathione levels in the striatum.”

“Proulcerogenic effect of atorvastatin are likely to be associated with decreased mucosal defense mechanisms ( GSH and PGE2), and increased neutrophil infiltration and proinflammatory factors (TNF-a and iNOS) possibly via independently from mevalonate pathway.”

“Only ATV at 10 mg/kg/day decreased reduced glutathione (GSH) levels and superoxide dismutase (SOD) activity, increased malondialdehyde (MDA) levels, and elicited histopathological changes in the liver.”

“Administration of ATO enhanced ALT, ALP level, increased reactive oxygen species (ROS) production and altered the pro oxidant-antioxidant status of liver by reducing intracellular GSH level, anti-oxidant enzymes activities and increasing intracellular lipid peroxidation.”

“ Atorvastatin in all the tested doses suppressed the development of kindling, reduced lipid peroxidation, and increased glutathione levels.”

“ Atorvastatin (80 mg/day for 14.5 months) significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of aged beagles.”

“This remarkable effect of atorvastatin is accomplished at least by decreasing oxidative stress and neutrophil accumulation as well as preventing the depletion of reduced glutathione.”

“ Atorvastatin increased cytochrome C expression and caspase activity in a dose-dependent manner, and increased the activity of antioxidative enzymes, such as GPx, SOD, GST, reduced glutathione , and catalase, and reduced the level of nitrate and LPO.”