Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency.

The association suggests that every 1-mol change in

 is accompanied by a change of approximately 0.5 mol in 

UVA Light-excited Kynurenines Oxidize Ascorbate and Modify Lens Proteins through the Formation of Advanced Glycation End Products

Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models.

 in treating cancer, and therefore iv AA and iv GSH should not be coadministered to cancer patients on the same day.

Stimulation of synthesis of mevalonate-derived nonsterols by ascorbate and glutathione in liver.

 up to 0.05 M were stimulatory, but at higher concentrations both were inhibitory.

Toxicological Antagonism among Welding Fume Metals: Inactivation of Soluble Cr(VI) by Iron

 was a significant contributor to reduction of Cr(VI) by Fe only in the presence of 

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.

Cell death as a consequence of the action of

 levels, prosurvival signaling (p-NF-κB, p-ERK1/2), and in expression of X-linked inhibitor of apoptosis protein, the most potent caspase inhibitor.

Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in human bladder-derived T24 cells.

 increased ROS formation (4-fold) and depleted 

Reduction of NO-induced methemoglobinemia requires extremely high doses of ascorbic acid in vitro

Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes.

There was a strong positive correlation between

Effect of antioxidant supplementation on the adaptive response of human skin fibroblasts to UV-induced oxidative stress.

 also reduced the magnitude of the adaptive increases in catalase and superoxide dismutase activities and increase in 

Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene.

The decrease in GSH by UVA radiation is not affected by the presence of the lipophilic antioxidants while

The cytoprotective roles of ascorbate and glutathione against nitrogen dioxide toxicity in human endothelial cells.

 into the cells significantly diminished NO2-dependent depletion of intracellular 

The results also strengthen the premise that

 co-operate in the antioxidative protection of cellular viability.

Effect of ascorbate or N-acetylcysteine treatment in a patient with hereditary glutathione synthetase deficiency.

 markedly increased lymphocyte (4-fold) and plasma (8-fold) levels of 

Regeneration of vitamin E in human platelets.

This finding implies that maintenance of membrane tocopherol status may be an essential function of

 which operate in concert to ensure maximum membrane protection against oxidative damage.

Lipid peroxidation and haemoglobin degradation in red blood cells exposed to t-butyl hydroperoxide. Effects of the hexose monophosphate shunt as mediated by glutathione and ascorbate.

Extracellular ascorbate functioned largely without a requirement for glucose metabolism, although some synergistic effects between extracellular

Protection by Ascorbate against Acetylphenylhydrazine‐Induced Heinz Body Formation in Glucose‐6‐Phosphate Dehydrogenase Deficient Erythrocytes

 which is depleted and act as a scavenger for drug free radicals generated during the reaction.

Non-invasive imaging of the levels and effects of glutathione on the redox status of mouse brain using electron paramagnetic resonance imaging.

GSH does not reduce nitroxides directly, but in the presence of

 increases ascorbate-induced reduction of nitroxides.

The effects of a high dose of ascorbate on ischemia-reperfusion-induced mitochondrial dysfunction in canine hearts

 reduced the mitochondrial dysfunction and prevented the depletion of mitochondrial 

 concentration after 2-h LAD occlusion and 1-h reperfusion.

Oxidative stress in fatty livers of obese Zucker rats: Rapid amelioration and improved tolerance to warm ischemia with tocopherol

 over 48 hours completely corrected the decreases in 

Oxidative stress induced by ascorbate causes neuronal damage in an in vitro system

 treatment decreased cellular glutathione (

) content, and increased the rates of lipid peroxide production in rat cortical slices.

Inhibition of purified soluble guanylyl cyclase by L-ascorbic acid.

 on sGC was largely antagonised by reduced 

 (1 mM) and the specific iron chelator diethylenetriaminepentaacetic acid (0.1 mM).

Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.

These data show a reciprocal action between falling

N-acetylcysteine or trolox derivative mitigate the toxic effects of methanol on the antioxidant system of rat brain.

 increased by about 17%, the concentration of 

 by 20%, while the thiobarbituric acid-reactive substances (TBA-rs) diminished to the values as in control group.

The Fate of the Oxidizing Tyrosyl Radical in the Presence of Glutathione and Ascorbate

Cellular systems contain as much as millimolar concentrations of both ascorbate and GSH, although the

When measuring the ascorbate radical directly using fast-flow electron spin resonance, only minor changes in the

 radical electron spin resonance signal intensity occurred in the presence of 

17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation.

 were simultaneously added to microsomal incubations, both metabolic pathways competed for the same pool of catechol estrogens, and 

 dramatically influenced which of these two pathways predominate.

Toxic and Protective Effects of l‐DOPA on Mesencephalic Cell Cultures

 (200 μM), an antioxidant, prevented the rise in 

Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice.

The findings support the view that the antioxidant actions of

 are closely linked and involve a mechanism in which decrease of the glutathione level, perhaps associated with an oxidative event, stimulates ascorbate synthesis.

Inhibition of protein carbonyl formation and lipid peroxidation by glutathione in rat liver microsomes.

 inhibited TBARS and protein carbonyl group formation in both 

 and NADPH systems in a dose-dependent manner.

Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

 levels decrease leading to formation of dehydroascorbate, which is degraded.

Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

There is apparent linkage between the antioxidant actions of

Studies on protection by glutathione against lipid peroxidation in rat liver microsomes. Effect of bromosulfophthalein.

Microsomal lipid peroxidation induced by ferrous-reduced incotinamide adenine dinucleotide phosphate (NADPH-Fe2+) or

, and addition of BSP abolished the protective effect of GSH in both peroxidation systems.

Effects of exogenous antioxidants on the levels of endogenous antioxidants, lipid-soluble fluorescent material and life span in the housefly, Musca domestica


 and beta-carotene at both concentrations administered.

Cytosolic factors which affect microsomal lipid peroxidation in lung and liver.

The effects of liver cytosol on hepatic microsomal lipid peroxidation can be duplicated by concentrations of ascorbate and glutathione normally found in the cytosol; i.e.,

 inhibits lipid peroxidation with the net effect being similar to that of liver cytosol.

Activation and inhibition of the adrenal steroid 21-hydroxylation system by cytosolic constituents: influence of glutathione, glutathione reductase, and ascorbate.

 is weaker with K i = 0.3 mM. In addition, adrenal cytosolic glutathione reductase has been isolated and characterized.

Exogenous glutathione alleviates chilling injury in postharvest bell pepper by modulating the ascorbate-glutathione (AsA-GSH) cycle.

Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

 supplementation can prevent oxidative damage, it also can deplete 

Oxidative stress response mechanism of Scenedesmus obliquus to ionic liquids with different number of methyl-substituents.

The activities of antioxidant enzymes, i.e., superoxide dismutase, catalase, peroxidase,

 peroxidase, and glutathione peroxidase, and the content of antioxidants, i.e., ascorbic acid and 

, changed in IL treatment with a concentration-dependent effect.

Exogenous Glutathione Increases Arsenic Translocation Into Shoots and Alleviates Arsenic-Induced Oxidative Stress by Sustaining Ascorbate–Glutathione Homeostasis in Rice Seedlings

These results indicated that the increase in

 redox state can be linked to an increase in the 

 redox ratio via the induction of the AsA–GSH cycle.

Silicon Confers Soybean Resistance to Salinity Stress Through Regulation of Reactive Oxygen and Reactive Nitrogen Species

In addition, Si application normalized the photosynthetic responses, such as transpiration rate (E) and net photosynthesis rate (PN) in salt-treated plants, and reduced the activity of

The strong reaction of simple phenolic acids during oxidative stress caused by nickel, cadmium and copper in the microalga Scenedesmus quadricauda.

Pearson correlation analysis indicated a strong negative correlation between

 and rosmarinic acid content (-0.670; p < 0.05) in NiCl2-treated samples and reduced 

 and 3,4-dihydroxyphenylacetic content (-0.700; p < 0.05) in CdCl2-treated samples.

Exogenous ascorbic acid improves defence responses of sunflower (Helianthus annuus) exposed to multiple stresses.

While malondialdehyde content decreased, chlorophyll, carotenoid, ascorbate,

 contents and antioxidant enzyme activities increased in plants treated exogenously with 

A Low Glutathione Redox State Couples with a Decreased Ascorbate Redox Ratio to Accelerate Flowering in Oncidium Orchid.

 redox state could be influenced by the lower 

Modulation of antioxidant defence system for arsenic detoxification in Indian mustard.

The As treatments significantly increased the activities of antioxidative enzymes (superoxide dismutase,

 peroxidase and glutathione reductase) and the contents of antioxidants metabolites (

 and ascorbate), the increase being dependent on exposure time.

Effects of aluminum on light energy utilization and photoprotective systems in citrus leaves.

Activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), glutathione reductase (GR) and catalase (CAT), and concentrations of ascorbate 

), dehydroascorbate (DASA), reduced glutathione (

) and oxidized glutathione (GSSG) were higher in Al-treated than in control leaves. *

Light-dependent reduction of dehydroascorbate and uptake of exogenous ascorbate by spinach chloroplasts

The GSSG could replace GSH in which case the production of

Artificially increased ascorbate content affects zeaxanthin formation but not thermal energy dissipation or degradation of antioxidants during cold-induced photooxidative stress in maize leaves

 appeared to increase the requirement for reduced 

Peroxide processing in photosynthesis: antioxidant coupling and redox signalling.

This review focuses on compartment-specific differences in the stringency of redox coupling between

, and the significance this may have for the flexibility of the control of gene expression that is linked to photosynthetic H2O2 production.

Enhancement of peroxidase-induced lipid peroxidation by indole-3-acetic acid: effect of antioxidants.

α-Tocopherol or β-carotene in the lipid phase or

 or Trolox in the aqueous phase inhibited the loss of fluorescence induced by the peroxidase + IAA system, but 

Reaction of ferric leghemoglobin with H2O2: formation of heme-protein cross-links and dimeric species.

 inhibit both this intermolecular dimer formation and the formation of the intramolecular haem-protein cross-links and are likely to play a protective role in vivo.

Effects of glutathione and chelating agents on copper-mediated DNA oxidation: pro-oxidant and antioxidant properties of glutathione.

Parallel ESR spin trapping measurements indicated that

 inhibits free radical formation by copper ions in the presence of H2O2, 

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Possible Interaction: Glutathione and Ascorbate

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Research Papers that Mention the Interaction