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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Glutathione and Ascorbate

supplement:

Glutathione

supplement:

Ascorbate

Research Papers that Mention the Interaction

The association suggests that every 1-mol change in ascorbate is accompanied by a change of approximately 0.5 mol in glutathione.
The American journal of clinical nutrition  •  2003  |  View Paper
High levels of GSH inhibited but did not completely block ASC oxidation.
The Journal of Biological Chemistry  •  2014  |  View Paper
There is an antagonism between ascorbate and glutathione in treating cancer, and therefore iv AA and iv GSH should not be coadministered to cancer patients on the same day.
Free radical biology & medicine  •  2011  |  View Paper
Concentrations of glutathione and ascorbate up to 0.05 M were stimulatory, but at higher concentrations both were inhibitory.
The effects of glutathione and ascorbate were additive.
The International journal of biochemistry  •  1981  |  View Paper
Glutathione was a significant contributor to reduction of Cr(VI) by Fe only in the presence of ascorbate.
Chemical research in toxicology  •  2018  |  View Paper
Cell death as a consequence of the action of MnP+ascorbate corresponded to decreases in GSH levels, prosurvival signaling (p-NF-κB, p-ERK1/2), and in expression of X-linked inhibitor of apoptosis protein, the most potent caspase inhibitor.
Free radical biology & medicine  •  2014  |  View Paper
In juglone-treated cells, ascorbate increased ROS formation (4-fold) and depleted GSH (65%).
Biochemical and biophysical research communications  •  2012  |  View Paper
Treatment with 10 mM ascorbate significantly decreased glutathione (p < 0.002).
Intensive Care Medicine  •  2009  |  View Paper
There was a strong positive correlation between glutathione and ascorbate (r = 0.62, P < 0.001).
The American journal of clinical nutrition  •  2000  |  View Paper
At low doses, ascorbate supplements also reduced the magnitude of the adaptive increases in catalase and superoxide dismutase activities and increase in glutathione content.
Redox report : communications in free radical research  •  1999  |  View Paper
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