Possible Interaction: Glutathione and Alpha-lipoic acid

“Baseline GSH was lower (P<0.05) in D compared to N group whereas LA supplementation for 2 and 4 weeks increased significantly (P<0.05) GSH levels in both groups.”

“ Alpha-lipoic acid is an antioxidant able to increase the levels of intracellular glutathione and eliminate free radicals.”

“The combination of FO and LA also significantly elevated hepatic antioxidant defense capacities, as evaluated by the remarkable increase in the activities of SOD, CAT and GPx as well as the level of GSH , and the significant decline in lipid peroxidation.”

“Along with its reduced form dihydrolipoic acid (DHLA), LA reduces and recycles cellular antioxidants such as glutathione , and chelates zinc, copper and other transition metal ions in addition to heavy metals.”

“ a-Lipoic acid inhibits intercellular adhesion molecule 1 and increases levels of glutathione , another endogenous antioxidant, by its action in reducing the oxidized amino acid cysteine to cystine.”

“Hence lipoic acid may have clinical relevance in restoration of severely glutathione deficient cells.”

“We … that alpha-lipoic acid may take over some … the functions of glutathione (e.g., maintaining the higher level of ascorbate, indirect participation in vitamin E recycling); the increase of glutathione level in lens tissue mediated by lipoate could be also due to a direct protection of protein thiols.”

“ Thioctic acid also has been found to elevate the level of glutathione and reactive oxidants, and increase CD4 and CD8 levels in PWAs.”

“The antioxidant α-lipoic acid (ALA) has shown to modulate GSH pathways.”

“Supplementation with phase 2 inducers—such as lipoic acid —can likewise increase glutathione levels by promoting increased GCL expression.”