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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“In addition, the mitochondrial transport of GSH and 2‐oxoglutarate in isolated mitochondria from rat liver exhibited mutual competition and sensitivity to glutamate and phenylsuccinate.”
Sensitivity of the 2‐oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion“In whole RBCs partially … glutamate, 10 mm extracellular α‐ketoglutarate , but not 10 … the rate of GSH synthesis (0.85 ± 0.09 and 0.61 ± 0.18 μmol·(L RBC)−1·min−1, ….52 ± 0.09 μmol·(L RBC)−1·min−1 for RBCs without an external glutamate source.”
“The addition of both 2-oxoglutarate and glutathione resulted in a 20-fold increase in sulfate formation.”
Formation of sulfate from L-cysteine in rat liver mitochondria.“Addition of 2-oxoglutarate and GSH resulted in more than 3-fold increase in sulfate formation, and thiosulfate was formed besides sulfate.”
l-Cysteine metabolism via 3-mercaptopyruvate pathway and sulfate formation in rat liver mitochondria
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