Possible Interaction: Glutathione and Allicin

“ Allicin increased the glutathione level in a concentration and time-dependent manner up to 8-fold at a concentration of 10–20 µM after 28 h exposure.”

“Indeed, allicin depleted GSH in the cytosol and mitochondria, and buthionine sulfoximine, a specific inhibitor of GSH synthesis, significantly augmented allicin-induced apoptosis.”

“ Allicin caused a transient drop in the intracellular glutathione ( GSH ) level, the magnitude and kinetics of which significantly varied depending on cell type.”

“On the basis of these findings, we suggest that allicin plays a major role in the antiproliferative effect of water-soluble garlic preparations and that this effect may be attributed to the ability of allicin to transiently deplete the intracellular GSH level.”

“The extent of the decrease in GSH levels correlated well (r = 0.75) with the growth inhibitory activity of allicin.”

“However, our data showed the oral administered allicin with a concentration of 5, 10, and 20 mg/kg b.w./day could significantly decrease the damage indexes of AST, ALT, LDH, BUN, ROS, 8-OHdG, MDA, and MPO, while increase the antioxidant indicators of SOD, GST and GSH.”

“Our data … orally administered allicin of 5, 10, and 20 mg kg⁻¹ bw d⁻¹ could significantly decrease thiobarbituric reactive substances (… (MPO) levels, and simultaneously remarkably increased the superoxide dismutase (SOD) activity, glutathione S-transferase (GST) and glutathione (GSH) levels in the kidney, … of the AA-treated mice.”

“ Allicin also markedly increased the activity of total superoxide dismutase (SOD) and level of glutathione (GSH).”

“ Allicin (diallyl thiosulfinate), a reactive sulfaorganic compound, increases cellular GSH and phase II detoxifying enzymes in vascular endothelial cells (EC).”

“Furthermore, allicin could significantly enhance the content of hepatic reduced glutathione ( GSH ), and the activities of hepatic glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Re) and GST in ethanol-induced hepatotoxicity mice.”

“Reduced glutathione reversed the action of allicin.”

“Reduced glutathione reversed the inhibitory action of allicin.”