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Last Updated: 4 years ago

Possible Interaction: Glutathione and Acetylcysteine Amide

supplement:

Glutathione

Research Papers that Mention the Interaction

The glutathione (GSH)-replenishing capacity was found to be three to four-fold higher after the administration of NACA compared to that observed after the administration of NAC.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2019  |  View Paper
Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione ( GSH ) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.
Biochimica et biophysica acta  •  2008  |  View Paper
NACA also significantly increased the levels of intracellular glutathione ( GSH ) and glutathione peroxidase (GPx).
Brain Research  •  2009  |  View Paper
NACA significantly increased GSH levels and the GSH/GSSG ratio in the liver to 66.5% and 60.5% of the control, respectively; and it reduced the level of ALT by 30%.
Toxicology letters  •  2016  |  View Paper
NACA at 750 μM substantially reduced the levels of ROS and lipid peroxidation, as well as increased both GSH level and GSH/GSSG ratio.
BMC pharmacology  •  2009  |  View Paper
A newly developed antioxidant, small molecular weight thiol compound, N-acetylcysteine amide (AD4) has been shown to increase cellular levels of glutathione and to attenuate oxidative stress related disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
Experimental & molecular medicine  •  2007  |  View Paper
NACA significantly increased the levels of intracellular GSH , CAT, and GR and decreased the levels of MDA in RBE4 cells, showing that oxidatively challenged cells were protected.
Experimental Neurology  •  2006  |  View Paper
NACA prevented glutamate-induced intracellular GSH loss.
Brain Research  •  2005  |  View Paper