Possible Interaction: Glutathione and Acetylcysteine Amide

“The glutathione (GSH)-replenishing capacity was found to be three to four-fold higher after the administration of NACA compared to that observed after the administration of NAC.”

“Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione ( GSH ) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.”

“ NACA also significantly increased the levels of intracellular glutathione ( GSH ) and glutathione peroxidase (GPx).”

“ NACA significantly increased GSH levels and the GSH/GSSG ratio in the liver to 66.5% and 60.5% of the control, respectively; and it reduced the level of ALT by 30%.”

“ NACA at 750 μM substantially reduced the levels of ROS and lipid peroxidation, as well as increased both GSH level and GSH/GSSG ratio.”

“A newly developed antioxidant, small molecular weight thiol compound, N-acetylcysteine amide (AD4) has been shown to increase cellular levels of glutathione and to attenuate oxidative stress related disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.”

“ NACA significantly increased the levels of intracellular GSH , CAT, and GR and decreased the levels of MDA in RBE4 cells, showing that oxidatively challenged cells were protected.”

“ NACA prevented glutamate-induced intracellular GSH loss.”