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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Glutathione
Research Papers that Mention the Interaction
“Because the epithelial cells were more sensitive to toxicity, glutathione conjugation evidently plays only a minor role in PhIP toxicity and mutagenicity in our cell lines.”
“Since PhIP may be detoxified by conjugation with glutathione , we measured glutathione levels and glutathione‐S‐transferase expression and activities in both cell lines.”
2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)–induced mutagenesis in cultured Big Blue™ rat mammary epithelial and fibroblast cells“Exposure to PhIP for 4 weeks induced oxidative damage and DNA damage in the colons, and disrupted the expression of related genes involved in tryptophan metabolism, beta(β)-alanine metabolism, valine, leucine, and isoleucine degradation, and glutathione metabolic pathways.”
Sub-chronic exposure to PhIP induces oxidative damage and DNA damage, and disrupts the amino acid metabolism in the colons of Wistar rats.“These data show a relationship between intracellular GSH concentration and the mutagenicity of PhIP.”
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