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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Glutathione and 1-(2-Chloroethyl)-1-Nitrosourea (Cnu)

Research Papers that Mention the Interaction

We propose that such interactions between GSH and the CENUs may constitute an important aspect of CENU metabolism and provide a potential means by which brain tumor cells can circumvent CENU toxicity and exhibit resistance to this class of agents.
Cancer research  •  1989  |  View Paper
Reaction of CNUs with glutathione (GSH) offers a better estimation of carbamoylating potential in vitro.
The decrease in free thiol groups during incubation of GSH with various CNUs can be followed using the thiol reagent 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB).
Various carbamoylated and alkylated GSH derivatives, such as S-(2-chloroethylcarbamoyl)-, S-(2-hydroxyethylcarbamoyl)-, S-(cyclohexylcarbamoyl)-, S-(4-methylcyclohexylcarbamoyl)- and S-(2-hydroxyethyl)glutathione, are formed on incubation of GSH with CNUs.
IARC scientific publications  •  1987  |  View Paper