Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Glutamine and Vigabatrin

supplement:

Glutamine

Research Papers that Mention the Interaction

Gln was increased by 1.9 μmol/g and Glu was decreased by 0.8 μmol/g in patients receiving VGB as compared with patients receiving standard medications alone.
Epilepsia  •  1995  |  View Paper
In addition, GVG caused a biphasic change in glutamine concentrations (a decline 1–4 hours after administration, followed 20 hours later by an increase).
Journal of Neural Transmission  •  2005  |  View Paper
Repeated subcutaneous injections of the antiepileptic GABA transaminase inhibitor gamma-vinylGABA at a dose of 150 mg/kg per day for 21 days reduced glutamine synthetase activity by 36% in the cortex and 22% in the cerebellum.
Journal of neurochemistry  •  1995  |  View Paper
In addition, γ‐vinyl GABA caused a marked increase in hypotaurine content in rat brain, suggesting that it acts as an inhibitor of hypotaurine dehydrogenase, and it produced significant decreases in brain contents of glutamine and threonine.
Journal of neurochemistry  •  1979  |  View Paper