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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutamine
drug:
Vigabatrin
Research Papers that Mention the Interaction
“ Gln was increased by 1.9 μmol/g and Glu was decreased by 0.8 μmol/g in patients receiving VGB as compared with patients receiving standard medications alone.”
Initial Observations on Effect of Vigabatrin on In Vivo 1H Spectroscopic Measurements of γ‐Aminobutyric Acid, Glutamate, and Glutamine in Human Brain“In addition, GVG caused a biphasic change in glutamine concentrations (a decline 1–4 hours after administration, followed 20 hours later by an increase).”
γ-Vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice“Repeated subcutaneous injections of the antiepileptic GABA transaminase inhibitor gamma-vinylGABA at a dose of 150 mg/kg per day for 21 days reduced glutamine synthetase activity by 36% in the cortex and 22% in the cerebellum.”
“In addition, γ‐vinyl GABA caused a marked increase in hypotaurine content in rat brain, suggesting that it acts as an inhibitor of hypotaurine dehydrogenase, and it produced significant decreases in brain contents of glutamine and threonine.”
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