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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Glutamine and Vigabatrin



Research Papers that Mention the Interaction

Gln was increased by 1.9 μmol/g and Glu was decreased by 0.8 μmol/g in patients receiving VGB as compared with patients receiving standard medications alone.
Epilepsia  •  1995  |  View Paper
In addition, GVG caused a biphasic change in glutamine concentrations (a decline 1–4 hours after administration, followed 20 hours later by an increase).
Journal of Neural Transmission  •  2005  |  View Paper
Repeated subcutaneous injections of the antiepileptic GABA transaminase inhibitor gamma-vinylGABA at a dose of 150 mg/kg per day for 21 days reduced glutamine synthetase activity by 36% in the cortex and 22% in the cerebellum.
Journal of neurochemistry  •  1995  |  View Paper
In addition, γ‐vinyl GABA caused a marked increase in hypotaurine content in rat brain, suggesting that it acts as an inhibitor of hypotaurine dehydrogenase, and it produced significant decreases in brain contents of glutamine and threonine.
Journal of neurochemistry  •  1979  |  View Paper