Possible Interaction: Glutamine and Somatropin

“With rhGH , the intestinal absorption of leucine and glutamine increased (P = 0.036) and correlated with serum insulin (r = 0.91, P = 0.002).”

“ rhGH increased glutamine de novo synthesis (P < 0.02) and plasma concentrations (P < 0.03) in both fasting and fed states.”

“The combined GLN plus rhGH regimen had similar effects as rhGH alone.”

“BACKGROUND & AIMS Both recombinant human growth hormone (rhGH) and glutamine (GLN) may have beneficial anabolic actions on amino acid metabolism.”

“Thus net glutamine release from muscle into circulation significantly decreased after rhGH administration ( approximately 50%), whereas glutamine synthetase mRNA levels increased after rhGH infusion, possibly to compensate for reduced glutamine precursor availability.”

“We conclude that, after trauma, the anticatabolic action of rhGH is associated with a potentially harmful decrease in muscle glutamine production.”

“In 2 mM Gln, rhGH decreased Gln net uptake 84% (1,096 +/- 215 to 155 +/- 150 nmol/4 h, P < 0.05), with basolateral uptake reversing to release; Glu- formation increased as ammonium production decreased.”

“p less than 0.05) Rates of whole body protein turnover Q ), together with those of synthesis (S) and breakdown (B) were significantly higher in HGH group than in control group. (”

“Only patients who received HGH with glutamine maintained statistically significant PN reductions at 3 month follow-up.”

“Optimal clinical benefits appear to be achieved when r-hGH is administered in combination with a specialized oral diet and perhaps with glutamine.”

“The plasma albumin level in Gln + rhGH group was obviously higher than that in C and Gln groups on the 21st PBD (P < 0.05).”

“The total hospital stay days in Gln + rhGH group were obviously less than that in C and Gln groups (P < 0.05 or 0.01).”

“The plasma levels of total amino acids including the branched chain amino acids valine, leucine and isoleucine and of glutamine were significantly higher during r-HGH infusion than during the basal and somatostatin periods.”