Possible Interaction: Glutamine and Sodium Chloride

“ GLN stimulates absorption in rotaviral (3) and cryptosporidial enteritis (4), augments glucose in promoting Na absorption (5), and has the unusual effect of stimulating NaCl absorption even when administered to the serosal surface of the intestine (5).”

“Sodium depletion (9.0 mM NaCl ) greatly diminished glutamine transport in resting and stimulated cells.”

“We propose that glutamine protects against high concentrations of NaCl in the medium by acting as an organic osmolyte.”

“When the NaCl concentration is low, glutamine inhibits development.”

“Differential scanning calorimetry analysis indicated that Q protected the thermal stability from destruction at 50 mM and 200 mM NaCl concentrations, with narrower protein denaturation peaks.”

“During a study of the effects of a high level of NaCl on the content of free intracellular amino … of glucose it was found (Malaneyet al. 1988, 1989; Malaney and Tanner 1988) that 0.6 mol/L exogenous NaCl …, glutamine , ornithine, arginine and lysine (all … mol/L exogenous NaCl. (”

“For early culture times (6 h), the production of glutamine , citrulline, valine, isoleucine, ornithine, lysine and histidine were all enhanced by the addition of NaCl.”

“ NaCl treatment brings about a destabilization of QA and QB, leading to a decrease in Q and B bands in the leaves.”

“Osmotic stress produced by NaCl , in contrast, inhibited the transport of glutamine and some other amino acids.”

“In culture, addition of NaCl stimulates glutamine synthetase activity and lowers glutamine dehydrogenase activity in the aerial organs and in the roots of Suaeda as opposed to what is observed in the glycophyte.”