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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Glutamine , a well-established oncometabolite, anaplerotically fuels mitochondrial energy metabolism and modulates activity of mammalian/mechanistic target of rapamycin complexes (mTOR).”
Inhibition of mTOR complexes protects cancer cells from glutamine starvation induced cell death by restoring Akt stability.“ Rapamycin reduced the level of 2-HG sourced mainly from glutamine and glucose derived lactate which correlated to the decreased incorporation of 13C atoms from 13C-substrates.”
“Alteration in astrocyte volume in the presence of sirolimus was accompanied by reduction of the following important cell osmolytes and amino acid metabolites: myo-inositol, -58 +/- 12% (mean +/- standard deviation, n = 5); taurine, -44 +/- 5%; glutamine , -13 +/- 2%; compared with control.”
Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy.“ Sirolimus significantly increased the rate of incisional hernia formation from 3.7% (CI 95% 1.7–7.1, p < 0.001) to 18.1% (CI 95% 11.7–27, p < 0.001), Q (1) = 13.97, p < 0.001.”
Optimal surgical management in kidney and pancreas transplantation to minimise wound complications: A systematic review and meta-analysis“In contrast, rapamycin could significantly suppress the glutamine inducing effect on AFs production, simultaneously inhibiting the fungal growth and conidiation.”
“Supplementing functional amino acids (e.g., arginine and glutamine ) and vitamins (e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation.”
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