supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Decreased glutamate transport may result in elevated extracellular glutamate levels, 1 and both riluzole and gabapentin block presynaptic release of glutamine.”
Reduction of fasciculations in patients with amyotrophic lateral sclerosis with the use of gabapentin.“1) MeHg induced Hg accumulation, pathological injury, and apoptosis of cortex; (2) …, and carbonyl, and inhibited sulfydryl and GSH; (3) MeHg elevated Glu, decreased Gln , and downregulated GLAST and … protein levels; (4) riluzole antagonized MeHg-induced downregulation of GLAST and GLT-… depletion, oxidative stress, pathological injury, and apoptosis obviously.”
Riluzole-Triggered GSH Synthesis via Activation of Glutamate Transporters to Antagonize Methylmercury-Induced Oxidative Stress in Rat Cerebral Cortex“These results suggested that Glu-Gln cycle was disrupted by Mn exposure dose dependently; riluzole might antagonize Mn neurotoxicity.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback