“ Glutamine might represent a synergistic agent of rifampicin to kill Mycobacteria persisters.”
“The reactive oxygen species level of the strains treated with rifampicin and glutamine increased.”
“The result showed that glutamine decreases M. smegmatis tolerance to rifampicin upon starvation.”
“The synergism of glutamine and rifampicin to kill persisters might derive from altering the oxidative phosphorylation and TCA cycle, as both evidenced by both ATP level increase and transcriptome change.”