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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutamine
drug:
Penicillins
Research Papers that Mention the Interaction
“When … in penicillin , the assimilatory processes become … that glutamic acid and glutamine can no longer be assimilated from the external environment, and, since the internal metabolic processes are not affected, the … glutamic acid within the cell falls until protein synthesis, and consequently growth, can no longer take place5,6.”
Correlation Between Penicillin Resistance and Assimilation Affinity in Staphylococcus Aureus“Infusion of penicillin at 41 bar reduced the levels of Glu by 20.1% and Gln by 21.0% in the intact neostriatum only, whereas it decreased the Asp level in both sides as compared to control.”
Penicillin-induced convulsions have preferential effects on transmitter glutamate pools in rat neostriatum“ Glutamine conferred a protective role against penicillin when added to the culture medium.”
“These genes are involved in glutamine synthesis and uptake and LC-MS work confirmed that penicillin treatment increases the intracellular glutamine concentrations.”
Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae“Their observation that the first physiologically evident effect of penicillin is inhibition of glutamine assimilation appears extremely significant, since glutamine is a component of glutathione, the activity of the -SH group of which is known to depend markedly on the vicinal NH groups.”
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