Possible Interaction: Glutamine and Ornithine

“RESULTS Glutamate but not gl tamine in gestion resulted in higher plasma orn ithine co ncentrations than did water ingestion (P < 0.01).”

“ Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming phenylacetylglutamine (PAGN) which is excreted in urine.”

“The glutamine solution decreased the levels of proline, ornithine and tyrosine in the plasma of rats eating the cafeteria diet.”

“ Ornithine induced more than 36‐fold the ornithine decarboxylase activity in confined Ehrlich ascites tumour cells after 3.5 h of continuous perifusion with 0.5 mM ornithine; arginine and glutamine also induced the activity 3‐ and 4‐fold, respectively.”

“In addition, excess Orn decreased both plasma ammonia and free glutamine (Gln) concentration in brain.”

“Incubation with glutamine increases tissue [ ornithine].”

“A total of 28 metabolites were identified as biomarkers for ovariectomized-osteoporosis model, … acid, LysoPC(15:0), l-carnitine, glucose, arginine, citric acid, corticosterone, ornithine, …), glutamine , uric acid, 8-HETE, estriol, which mainly related with 13 metabolic pathways, …, arginine and proline metabolism, citrate cycle (TCA cycle), and arginine biosynthesis.”