Possible Interaction: Glutamine and Norepinephrine

“The CO2 formation from labeled glutamine during 4 hr of incubation was enhanced about twofold in the presence of noradrenaline.”

“The findings suggest that noradrenaline stimulates the rates of glutamine uptake, glutamate synthesis, and CO2 production from glutamine and thus increases energy supply to astrocytes but has no effect on the opposite reaction, i.e., glutamine formation from glutamate, a reaction of importance for neuronal‐astrocytic interations.”

“Mg++, DL-2-amino-5-phosphonopentanoic acid and MK-801 (D-5-methyl-10,11,dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine maleate), but not 6-cyano-7-nitroquinoxaline-2,3-dione, inhibited the L-glutamic acid-evoked release of NE.”

“ Norepinephrine caused a decrease in D, mean red cell velocity (Vm) and Q within individual microvessels.”

“These data indicate that when NE reduced Q during exercise, the exercise induced in VO2 was protected to a greater degree than when MO reduced Q under similar conditions.”

“In accordance with previous workers, norepinephrine was found to increase glucose formation from lactate and pyruvate and to a smaller degree from malate, succinate, fumarate and glutamine.”