Possible Interaction: Glutamine and Nitroarginine

“ Nitroarginine increases glutamine synthesis slightly in intact astrocytes.5.”

“Injection of nitroarginine alone, in the absence of ammonia, induces a remarkable accumulation of glutamine and a decrease in glutamate.”

“ N-nitroarginine decreased basal concentrations of DOPAC and HVA, and increase basal concentrations of GLN , but had no effect on basal DA, GLU, and GABA.”

“Pre-incubation of the slices with L-NG-nitroarginine , a competitive inhibitor of nitric oxide synthase, effectively prevented the NMDA-induced reduction in glutamine synthetase and neuron specific enolase, but did not diminish the kainate-induced decrease in the activity of either enzyme.”

“ L-Gln (200 microM) but not D-Gln (200 microM) potentiated the inhibitory effect of N omega-nitro-L-arginine (30 microM ), an inhibitor of EDRF biosynthesis, on Ach-induced relaxations of rabbit aortic strips, whereas L-Gln alone had no effect.”