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Discover Supplement-Drug Interactions

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Possible Interaction: Glutamine and Methotrexate

supplement:

Glutamine

Research Papers that Mention the Interaction

We conclude that oral glutamine can decrease the severity and duration of oropharyngeal mucositis in autologous BMT patients but not in allogeneic BMT patients, possibly due to interaction with methotrexate.
Bone Marrow Transplantation  •  1998  |  View Paper
He was receiving treatment with glutamine when the third course of methotrexate was administered (5 g/m(2)) and he suffered a deterioration in his renal function.
Anales de pediatria  •  2009  |  View Paper
Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy.
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology  •  2012  |  View Paper
Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect.
Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect.
Annals of surgery  •  1998  |  View Paper
In conclusion, IT MTX induces persistent alterations in glutaminergic tone that may contribute to persistent cognitive deficits.
Behavioural Brain Research  •  2011  |  View Paper
The provision of supplemental GLN in the diet increased methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for the +GLN group vs 28.8 +/-
GLN … methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for the +GLN group vs 28.8 +/- 0.10 … and 35.6 +/- 0.18 nmol/g for the +GLN group vs 32.5 +/- 0.16 nmol/g for the -GLN group, respectively).
Archives of surgery  •  1992  |  View Paper
The authors hypothesized that supplemental oral glutamine GLN ) would increase the therapeutic index of methotrexate (MTX) by improving host tolerance through changes in glutathione metabolism.
Annals of surgery  •  1995  |  View Paper
In rats receiving methotrexate , the tumor volume loss was nearly doubled when glutamine was added to the diet.
JPEN. Journal of parenteral and enteral nutrition  •  1992  |  View Paper