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Discover Supplement-Drug Interactions
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Last Updated: 3 months ago
supplement:
Glutamine
drug:
Methotrexate
Research Papers that Mention the Interaction
“We conclude that oral glutamine can decrease the severity and duration of oropharyngeal mucositis in autologous BMT patients but not in allogeneic BMT patients, possibly due to interaction with methotrexate.”
Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation“He was receiving treatment with glutamine when the third course of methotrexate was administered (5 g/m(2)) and he suffered a deterioration in his renal function.”
“ Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy.”
Glutamine: A novel approach to chemotherapy-induced toxicity“Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect. ”
“Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect.”
“In conclusion, IT MTX induces persistent alterations in glutaminergic tone that may contribute to persistent cognitive deficits.”
“The provision of supplemental GLN in the diet increased methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for the +GLN group vs 28.8 +/-”
“… GLN … methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for the +GLN group vs 28.8 +/- 0.10 … and 35.6 +/- 0.18 nmol/g for the +GLN group vs 32.5 +/- 0.16 nmol/g for the -GLN group, respectively).”
“The authors hypothesized that supplemental oral glutamine GLN ) would increase the therapeutic index of methotrexate (MTX) by improving host tolerance through changes in glutathione metabolism.”
Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism.“In rats receiving methotrexate , the tumor volume loss was nearly doubled when glutamine was added to the diet.”
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