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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Glutamine and Methotrexate



Research Papers that Mention the Interaction

Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect.
Annals of surgery  •  1998  |  View Paper
We conclude that oral glutamine can decrease the severity and duration of oropharyngeal mucositis in autologous BMT patients but not in allogeneic BMT patients, possibly due to interaction with methotrexate.
Bone Marrow Transplantation  •  1998  |  View Paper
In conclusion, IT MTX induces persistent alterations in glutaminergic tone that may contribute to persistent cognitive deficits.
Behavioural Brain Research  •  2011  |  View Paper
GLN … methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for the +GLN group vs 28.8 +/- 0.10 … and 35.6 +/- 0.18 nmol/g for the +GLN group vs 32.5 +/- 0.16 nmol/g for the -GLN group, respectively).
Archives of surgery  •  1992  |  View Paper
He was receiving treatment with glutamine when the third course of methotrexate was administered (5 g/m(2)) and he suffered a deterioration in his renal function.
Anales de pediatria  •  2009  |  View Paper
Glutamine decreases methotrexate systemic clearance, thus exposing the host as well as the tumor to greater methotrexate concentrations.
Nutrition  •  1995  |  View Paper
The authors hypothesized that supplemental oral glutamine GLN ) would increase the therapeutic index of methotrexate (MTX) by improving host tolerance through changes in glutathione metabolism.
Annals of surgery  •  1995  |  View Paper
Glutamine supplementation enhances the tumoricidal effectiveness of methotrexate while reducing its morbidity and mortality in this sarcoma rat model.
In rats receiving methotrexate , the tumor volume loss was nearly doubled when glutamine was added to the diet.
JPEN. Journal of parenteral and enteral nutrition  •  1992  |  View Paper
In studies with the Ehrlich ascites tumor accumulation of methotrexate polyglutamates was increased over 5-fold by the addition of 5 mM L-glutamine or L-glutamate and exhibited a positive correlation with the extracellular concentration of methotrexate.
Advances in experimental medicine and biology  •  1983  |  View Paper
Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy.
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology  •  2012  |  View Paper