Possible Interaction: Glutamine and Methionine

“The cell cycle showed a higher percentage of cells in the phases S, G2 and M when they were treated with 2 or 10 mM glutamine , or with glutamine and taurine in cells stimulated with lipopolysaccharide.”

“In sheep, at least, glutamine may exert a protective effect against hepatic amino acid (AA) oxidation, particularly for methionine.”

“ Methionine sulphoximine treatment for 4 days resulted in a 50% decrease in arterial glutamine concentration.”

“Abstract: … of L‐glutamine (2 mM) by rat brain cortex slices against a concentration gradient is markedly inhibited (40%) by branched‐chain Lamino acids (1 mM), L‐phenylalanine (1 mM), or L‐methionine (1 mM); that of L‐asparagine (2 mM) is much less affected by these amino acids.”

“Cysteine, leucine, valine, methionine , isoleucine, tyrosine, lysine, and phenylalanine increased the rate of glutamine synthesis.”

“These effects of methionine sulphoximine are reversed by glutamine.”

“Moreover, in wild-type yeast grown in these nutrient-limited conditions, supplementation with methionine stimulated glutamine consumption for synthesis of nitrogenous metabolites, demonstrating integration of a sulfur-containing amino acid cue and nitrogen utilization.”

“The one-electron reduction potentials of quinones (PQ, PTQ, and Q ) are largely positively shifted in the presence of M (n+).”

“A methionine auxotroph with a defect only in the metP system, which was dependent upon the glnP+ system for the transport of methionine sulfoxide, was inhibited by L-glutamine because glutamine inhibited the transport of the sulfoxide by the glnP+ system.”

“Activities of both glutamine synthetase and glutamate synthetase, two enzymes involved in the second pathway of glutamate synthesis, are inhibited by methionine sulfoximine and methionine sulfone.”