Possible Interaction: Glutamine and Methamphetamine

“Results In right inferior frontal cortex, N-acetyl-aspartate+N-acetyl-aspartyl-glutamate correlated with years of heavy methamphetamine use (r = +0.45); glutamate+glutamine was lower in methamphetamine users than in controls (9.3%) and correlated negatively with depressive symptoms (r = -0.44).”

“Results: In the methamphetamine group , small but significant (5–15%, P<.05) decrements (vs control) in glutamate+glutamine were observed in posterior cingulate, precuneus, and right inferior frontal cortex; glutamate+glutamine in posterior cingulate was negatively correlated (P<.05) with years of methamphetamine abuse.”

“Additionally, METH caused a significant decrease in glutamate and glutamine tissue content in PFC, and this effect was attenuated by CEF post-treatment.”

“Our findings indicate, for the first time, that methamphetamine decreases striatal glutamine , glutamate and GABA levels, as well as glutamine/glutamate and GABA/glutamate ratios, while serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels remain unchanged.”

“Both 0.5 and 5 microM METH also increased tritium release with 1 mM glutamine present.”

“Such a high frequency operation reveals Rayleigh-type phonon scattering losses due to highly diluted lattice impurities and corresponding glasslike behavior, with a … of 8.6×10(17) at 3.8 K and 4×10(17) at 15 mK. This suggests a limit on the Q ×f … crystal disorder.”