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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Glutamine and pyruvate weakly diminished the effects of metformin in 2D culture.”
Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations.“Targeted metabolomics studies revealed that the ability of metformin to interfere with the anaplerotic entry of glutamine into the tricarboxylic acid cycle could explain the hypersensitivity of IDH1-mutant cells to biguanides.”
“Compared with control cells, the presence of metformin dramatically lowered the molecular 13C carbon labeling (MCL) of the cellular TCA cycle intermediates citrate, α‐ketoglutarate, succinate, fumarate, and malate, as well as the MCL of the TCA cycle intermediate‐derived amino acids glutamate, glutamine , and aspartate.”
The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes“Inhibition of glutamine anaplerosis in the presence of metformin further attenuated proliferation, whereas increasing glutamine metabolism rescued the proliferative defect induced by metformin.”
“These data suggest that interfering with glutamine may synergize with metformin to improve outcomes in patients with prostate cancer.”
“In isolated hepatocytes from fasted rats, a significant inhibition of glucose production from lactate/pyruvate (10:1, mol/mol), fructose, alanine or glutamine , following metformin addition, is observed.”
“Post-irradiation MTH or Met treatment more clearly repressed the decrease in radio-sensitivity in the Q than total cells.”
Effect of Tirapazamine, Metformin or Mild Hyperthermia on Recovery From Radiation-Induced Damage in Pimonidazole-Unlabeled Quiescent Tumor Cells
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