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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Glutamine and Metformin

supplement:

Glutamine

Research Papers that Mention the Interaction

Glutamine and pyruvate weakly diminished the effects of metformin in 2D culture.
Biochemical and biophysical research communications  •  2019  |  View Paper
Targeted metabolomics studies revealed that the ability of metformin to interfere with the anaplerotic entry of glutamine into the tricarboxylic acid cycle could explain the hypersensitivity of IDH1-mutant cells to biguanides.
Oncotarget  •  2015  |  View Paper
Compared with control cells, the presence of metformin dramatically lowered the molecular 13C carbon labeling (MCL) of the cellular TCA cycle intermediates citrate, α‐ketoglutarate, succinate, fumarate, and malate, as well as the MCL of the TCA cycle intermediate‐derived amino acids glutamate, glutamine , and aspartate.
Journal of neuroscience research  •  2017  |  View Paper
Inhibition of glutamine anaplerosis in the presence of metformin further attenuated proliferation, whereas increasing glutamine metabolism rescued the proliferative defect induced by metformin.
These data suggest that interfering with glutamine may synergize with metformin to improve outcomes in patients with prostate cancer.
Cancer research  •  2013  |  View Paper
In isolated hepatocytes from fasted rats, a significant inhibition of glucose production from lactate/pyruvate (10:1, mol/mol), fructose, alanine or glutamine , following metformin addition, is observed.
European journal of biochemistry  •  1993  |  View Paper
Post-irradiation MTH or Met treatment more clearly repressed the decrease in radio-sensitivity in the Q than total cells.
World journal of oncology  •  2017  |  View Paper