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Last Updated: 2 years ago

Possible Interaction: Glutamine and Mersalyl

supplement:

Glutamine

Research Papers that Mention the Interaction

In addition, glutamine hydrolysis was strongly inhibited by mersalyl which is known to be impermeable to the inner mitochondrial membrane.
Neurochemistry International  •  1995  |  View Paper
Glutamine transport was found to be inhibited by L‐glutamate (IC50 = 0.64 mM) as well as thiol reagents ( mersalyl , N‐ethylmaleimide).
FEBS letters  •  1986  |  View Paper
Mersalyl completely inhibits glutamine influx into kidney and liver mitochondria indicating clearly that this process requires the presence of functional thiol groups and probably a specific glutamine carrier.
Current problems in clinical biochemistry  •  1977  |  View Paper
1) It was found that mersalyl completely inhibits uncoupled respiration of the mitochondria in the presence of glutamine as substrate, whereas respiration with glutamate was not affected.
The same amount of mersalyl which inhibits coupled oxidation of glutamine also inhibits coupled oxidation of glutamate and some other substrates. (
Biochimica et biophysica acta  •  1976  |  View Paper