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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In addition, glutamine hydrolysis was strongly inhibited by mersalyl which is known to be impermeable to the inner mitochondrial membrane.”
The orientation of phosphate activated glutaminase in the inner mitochondrial membrane of synaptic and non-synaptic rat brain mitochondria“ Glutamine transport was found to be inhibited by L‐glutamate (IC50 = 0.64 mM) as well as thiol reagents ( mersalyl , N‐ethylmaleimide).”
“ Mersalyl completely inhibits glutamine influx into kidney and liver mitochondria indicating clearly that this process requires the presence of functional thiol groups and probably a specific glutamine carrier.”
“1) It was found that mersalyl completely inhibits uncoupled respiration of the mitochondria in the presence of glutamine as substrate, whereas respiration with glutamate was not affected.”
“The same amount of mersalyl which inhibits coupled oxidation of glutamine also inhibits coupled oxidation of glutamate and some other substrates. (”
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