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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Glutamine and Melphalan



Research Papers that Mention the Interaction

In all cells studied, L amino acids (1 mM) such as leucine, glutamine , tyrosine, and methionine reduced the cell-to-medium ratio of melphalan at 3 and 35 min.
Cancer Chemotherapy and Pharmacology  •  2004  |  View Paper
Moreover, glutamine deprivation significantly enhanced cytotoxicity of L-PAM in all three cell lines, which was abolished after addition of GSH.ConclusionGlutamine deprivation decreased cell proliferation and enhances cell chemosensitivity in neuroblastoma, which is presumably associated with GSH depletion.
Journal of Cancer Research and Clinical Oncology  •  2007  |  View Paper
glutamine or leucine from RPMI 1630 medium increased the … a 35 min exposure of L1210 cells to melphalan by 10-fold and 2-fold, respectively, indicating that a substantial proportion of the protection afforded … from melphalan cytotoxicity in an amino acid environment can be attributed to these amino acids.
Molecular pharmacology  •  1978  |  View Paper
The LD90 for melphalan in the presence of 0.1 mM L-glutamine or L-leucine was increased by 7.3- and 10.8-fold respectively, under conditions where the cells had been pre-incubated with the amino acids.
Cancer treatment reports  •  1976  |  View Paper