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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In all cells studied, L amino acids (1 mM) such as leucine, glutamine , tyrosine, and methionine reduced the cell-to-medium ratio of melphalan at 3 and 35 min.”
Effects of amino acids on the transport and cytotoxicity of melphalan by human bone marrow cells and human tumor cells“Moreover, glutamine deprivation significantly enhanced cytotoxicity of L-PAM in all three cell lines, which was abolished after addition of GSH.ConclusionGlutamine deprivation decreased cell proliferation and enhances cell chemosensitivity in neuroblastoma, which is presumably associated with GSH depletion.”
“… glutamine or leucine from RPMI 1630 medium increased the … a 35 min exposure of L1210 cells to melphalan by 10-fold and 2-fold, respectively, indicating that a substantial proportion of the protection afforded … from melphalan cytotoxicity in an amino acid environment can be attributed to these amino acids.”
Amino acid conferred protection against melphalan: interference with leucine protection of melphalan cytotoxicity by the basic amino acids in cultured murine L1210 leukemia cells.“The LD90 for melphalan in the presence of 0.1 mM L-glutamine or L-leucine was increased by 7.3- and 10.8-fold respectively, under conditions where the cells had been pre-incubated with the amino acids.”
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