Possible Interaction: Glutamine and Lysine

“For the charge-neutralizing residues (glutamine and asparagine) in the calcium-binding site, our data showed that glutamine mutating to alanine or glutamate did not affect the channel activity, but glutamine mutating to lysine caused loss of function.”

“They are known for their transamidase activity that consists of the covalent crosslinking of glutamines and lysines.”

“It was predicted by employing the available algorithms that the replacement of a glutamine by lysine at position 3 could appreciably reduce its aggregation propensity in an aqueous environment.”

“Perfusion with 10 mm leucine, lysine , and histidine increased the rates of release of both glutamine and alanine.”

“This enzyme catalyzes the reaction between lysine and glutamine to form isopeptide cross-links.”

“The … 939 Gln alleles significantly increased HCC risk [OR = 1.25 (95% confidence ….03‐1.52) for heterozygotes of the XPC codon 939 Lys and Gln alleles (XPC‐LG) and OR = 1.81 (95% confidence interval = 1.….40) for homozygotes of the XPC codon 939 Gln alleles (XPC‐GG)].”

“Furthermore, peptides containing lysine at position -2 or -3 N-terminal to the target tyrosine were found to be poor EGFR kinase substrates, and substitution of these lysines with glutamine decreased the K(m) and increased the k(cat) for these substrates.”

“Both components … inhibited by L-lysine in a competitive fashion, suggesting … different systems were responsible for glutamine uptake: B(0), B(0,+), b(0,+) and L. All four systems were present during the … process, with systems L and B(0) being responsible for up to 80% of glutamine uptake.”

“Substitution of lysine at position 25 with either glutamate or glutamine completely abrogates binding to both mAb.”

“In solutions containing sodium the entry of lysine through the high‐affinity system (y+L) is inhibited by the neutral amino acids L‐leucine, L‐methionine and L‐glutamine with comparable high affinity.”